ANEMIA WORKSPACE
View summary

Clinical form for anemia evaluation. Required screening fields unlock advanced sections when anemia criteria are met.

Patient details
Required screening fields: * Sex, Age, Hemoglobin. Trimester is recommended when pregnant. Inline messages appear under invalid fields.
Units & reference ranges ℹ Some labs use 82 fL ℹ Some labs use 98 fL ℹ Typical reference ranges: • Men (18+): ~42-52% • Women (18+): ~37-47% • Pregnant women: ~33-36% (Ranges may vary by lab.)
Unit System: ℹ Toggle between International System (mmol/L, μmol/L) and US Conventional (g/dL, μg/dL) units.
Complete blood count ℹ WHO defines anemia in adults as: <13 g/dL for men, <12 g/dL for non-pregnant women, <11 g/dL for pregnant women. ℹ Anemias are classified into: • Microcytic (MCV <80 fL) • Normocytic (80–100 fL) • Macrocytic (>100 fL). ℹ Red cell distribution width reflects size heterogeneity. A high RDW can support mixed populations or early iron deficiency/megaloblastic change; interpret with smear and local reference range. ℹ Simplified correction factor based on anemia severity. ℹ Corrected retic % = Ret% × (Hct / Normal Hct). Adjusts reticulocyte % for anemia severity. ℹ RPI = Corrected retic % / maturation time. Helps classify underproduction vs hemolysis/blood loss. ℹ Absolute reticulocyte count ≈ Ret% × RBC (×10¹²/L) × 10, reported as ×10⁹/L. Often more informative than percentage alone. Values >120 ×10⁹/L typically indicate an adequate marrow response.      ℹ Mentzer index = MCV / RBC count.
Serum studies    ℹ Transferrin saturation (%) = (Serum Iron / TIBC) × 100     ℹ Often elevated in iron deficiency; helps distinguish from anemia of chronic disease. ℹ TR-F index = sTfR / ln(Ferritin). A higher index often suggests iron deficiency.     

ℹ Simplified CKD-EPI formula removing race factor, adapted from modern CKD-EPI guidance.
Hematology lab ℹ If hemolysis is not due to infection/drugs, check for GPI-anchor deficiency (PNH). ℹ Positive test suggests hereditary spherocytosis.

Medical history
Diagnosis summaryℹ Auto-generated from the app’s entered inputs and simplified rules. You can edit it manually; the app will not overwrite unless you click “Regenerate”.
This is a clinician-facing, editable summary that also appears in SOAP/SBAR prints and in the clipboard prompt.
Output preferences
Prompting techniques
Select a prompting strategy for the generated anemia prompt. The app can recommend the best technique from the selected task and entered clinical data.

Uses short examples to show the expected output format, useful for exam questions, Anki cards, or standardized clinical notes.

Requests a concise, clinician-facing reasoning summary without exposing hidden private chain-of-thought.

Asks the model to compare several plausible differential paths and return the most coherent answer.

Explores competing branches such as microcytic, normocytic, macrocytic, and hyperproliferative anemia before selecting a plan.

Structures reasoning and actions: identify missing data, request observations, then revise the anemia assessment.

Best for this tool’s sequential anemia logic: WHO threshold → RPI → MCV → iron/hemolysis/CKD pathways.

Structured prompt
Generate a complete, copy-ready AI prompt from the entered anemia data, selected output preferences, prompting techniques, and the app’s diagnostic logic.
How the algorithm worksOpen reference
Intelligent Map — How the algorithm works
Enter Sex and Hemoglobin to see the algorithm pathway.
ℹ This map explains the decision logic used by the app: WHO anemia threshold → RPI → MCV (if RPI ≤2) or hemolysis/blood loss (if RPI >2).
Algorithm at a glance Clickable clinical pathway
Anemia diagnostic algorithm visual pathway Click any pathway node to open the corresponding explanation in the Intelligent Map. RPI ≤ 2 RPI > 2 Required inputs Sex + Age + Hb WHO threshold Is anemia present? RPI Marrow response MCV branch Micro / normo / macro Hemolysis / loss If RPI > 2 Targeted tests Iron, RDW, B12, smear

Click any node in the image to jump to the matching explanation below. This visual is placed inside the Intelligent Map so the overview and interactive rule explanations stay together.

WHO anemia threshold Determines if advanced workup should open
→
RPI (marrow response) ≤2 underproduction vs >2 hyperproliferation
→
MCV subgrouping Used when RPI ≤2: micro/normo/macrocytic
→
Hemolysis / blood loss branch Used when RPI >2
→
Iron indices TSAT + ferritin + RDW + smear
Click a node above
to view what the app is doing at that stage and which fields it prioritizes.
Hematology notesOpen reference
Hematology notes
These are educational decision-support notes and do not replace clinician assessment or local guidelines.
Reticulocyte response first
  • After confirming anemia, use the reticulocyte response/RPI to separate impaired production from hemolysis or blood loss.
  • Low reticulocytes shift the workflow toward MCV-based classification and production defects.
MCV branches with mixed-pattern caution
  • Adult MCV patterns remain microcytic (<80 fL), normocytic (80–100 fL), and macrocytic (>100 fL).
  • A normal MCV can hide mixed populations, such as iron deficiency plus megaloblastic anemia; review RDW and smear.
Smear and RDW are not optional context
  • Peripheral smear helps confirm automated RBC-size classification and detect morphology seen in hemolysis or marrow disease.
  • High RDW supports anisocytosis and can appear early in iron deficiency or megaloblastic anemia.
Pattern-specific refinements
  • Microcytic low-retic anemia: prioritize iron deficiency, impaired iron use/inflammation, thalassemia/Hb E, sideroblastic anemia, and lead when relevant.
  • Normocytic low-retic anemia: consider inflammation, renal/EPO deficiency, endocrine or nutritional causes, PRCA, marrow infiltration, MDS, or aplasia when cytopenias/smear abnormalities coexist.
  • Macrocytosis: separate megaloblastic causes from alcohol/liver disease, hypothyroidism, MDS, reticulocytosis, and laboratory artifacts.
Evidence & referencesOpen reference
Evidence-based references
American / U.S.-relevant and NICE evidence sources used by this app include AGA guidance for gastrointestinal evaluation of iron-deficiency anemia, USPSTF recommendations on screening in pregnancy, ACOG guidance for anemia in pregnancy, AABB transfusion-threshold guidelines for escalation context, KDIGO/KDOQI nephrology guidance for anemia in CKD, and relevant NICE guidance including NG12 suspected cancer recognition and referral, NG24 blood transfusion, NG203 chronic kidney disease assessment and management, and NG88 heavy menstrual bleeding assessment and management. The diagnostic workflow is also refined with textbook hematology principles from Wintrobe’s Clinical Hematology, especially reticulocyte-response triage, MCV subgrouping, RDW/smear interpretation, and pattern-specific differential diagnosis. No single U.S. or NICE guideline covers the full diagnostic assessment of all adult anemia presentations; therefore, this app applies a structured clinical workflow integrating hemoglobin threshold, reticulocyte response, MCV pattern, RDW, peripheral smear, iron indices, renal function, hemolysis markers, nutritional deficiencies, inflammation, bleeding risk, and pregnancy/CKD-specific guidance.

Recent Class I and Class II evidence from the last five years is prioritized where available. Class I indicates systematic reviews, randomized trials, or formal evidence-based guidelines. Class II indicates prospective cohort evidence, secondary randomized-trial analyses, or high-quality observational evidence relevant to anemia diagnosis and management. Older NICE guideline components are retained where they remain current or have been incorporated into updated NICE guidance.
British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults Gut. 2021;70(11):2030–2051. Evidence class: Class I — evidence-based clinical guideline.
Open source
Interventions for treating iron deficiency anaemia in inflammatory bowel disease Gordon M, Sinopoulou V, Iheozor-Ejiofor Z, Iqbal T, Allen P. Cochrane Database of Systematic Reviews. 2021;1:CD013529. Evidence class: Class I — systematic review.
Open source
Transfusion thresholds for guiding red blood cell transfusion Cochrane Database of Systematic Reviews. 2021. Evidence class: Class I — systematic review of transfusion-threshold trials.
Open source
Red Blood Cell Transfusion: 2023 AABB International Guidelines Carson JL, Stanworth SJ, Guyatt G, et al. JAMA. 2023;330(19):1892–1902. Evidence class: Class I — evidence-based guideline using systematic reviews of randomized trials.
Open source
Effect of Low-Dose Aspirin vs Placebo on Incidence of Anemia in the Elderly Secondary analysis of the ASPREE randomized clinical trial. Annals of Internal Medicine. 2023. Evidence class: Class II — secondary randomized-trial analysis/prospective evidence.
Open source
KDIGO 2026 Clinical Practice Guideline for Anemia in Chronic Kidney Disease Kidney Disease: Improving Global Outcomes. Kidney International. 2026. Evidence class: Class I — formal evidence-based guideline using GRADE methodology.
Open source
NICE NG12 — Suspected cancer: recognition and referral National Institute for Health and Care Excellence. NICE guideline NG12. Published 2015; last updated 2026. Evidence class: Class I — formal evidence-based guideline. Relevant to anemia because the colorectal cancer pathway includes FIT for adults with iron-deficiency anaemia and adults aged 60+ with anaemia even without iron deficiency.
Open source
NICE NG24 — Blood transfusion National Institute for Health and Care Excellence. NICE guideline NG24. Published 2015; last updated 2026. Evidence class: Class I — formal evidence-based guideline. Relevant to escalation, transfusion assessment, and safe use of blood components.
Open source
NICE NG203 — Chronic kidney disease: assessment and management National Institute for Health and Care Excellence. NICE guideline NG203. Published 2021; last reviewed 2025. Evidence class: Class I — formal evidence-based guideline. Relevant to diagnosing, assessing, and managing anaemia associated with CKD.
Open source
NICE NG88 — Heavy menstrual bleeding: assessment and management National Institute for Health and Care Excellence. NICE guideline NG88. Published 2018; last updated 2026. Evidence class: Class I — formal evidence-based guideline. Relevant to menstrual blood loss as a cause of iron deficiency; NICE recommends a full blood count for all women with heavy menstrual bleeding.
Open source
AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review American Gastroenterological Association. Gastroenterology. 2024. Evidence class: Class II — expert review / best-practice advice synthesizing current evidence.
Open source
Treatment for women with postpartum iron deficiency anaemia Jensen MCH, Holm C, Jørgensen KJ, Schroll JB. Cochrane Database of Systematic Reviews. 2024. Evidence class: Class I — systematic review.
Open source
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies Cochrane Database of Systematic Reviews. 2024. Evidence class: Class I — systematic review of transfusion-threshold evidence in hematologic malignancy settings.
Open source
Anemia in Pregnancy: ACOG Practice Bulletin, Number 233 Obstetrics & Gynecology. 2021;138(2):e55–e64. Evidence class: Class I — professional guideline / practice bulletin.
Open source
Maternal anemia and severe maternal morbidity in a US cohort Harrison RK, Lauhon SR, Colvin ZA, McIntosh JJ. American Journal of Obstetrics & Gynecology MFM. 2021. Evidence class: Class II — cohort evidence on anemia-associated maternal morbidity.
Open source
Wintrobe’s Clinical Hematology, 14th edition Greer JP, Arber DA, Glader B, et al., editors. Wolters Kluwer; 2019. Evidence class: Authoritative hematology textbook/reference source — used for diagnostic-logic refinement rather than as a formal guideline.
User-supplied source; verify against current guidelines and local laboratory reference ranges.
OpenEvidence AI-assisted medical evidence search for clinicians. Evidence class: Evidence-search support resource — not a primary guideline or trial; use to retrieve and verify primary sources.
Open source